VASCULAR ENDOTHELIAL DYSFUNCTIONS WITH HYPERLIPOPROTEINEMIA

Authors

  • Azim Kenjayevich Baykulov Department of Pharmaceutical and Toxicological Chemistry, Samarkand State Medical University https://orcid.org/0000-0002-1139-1436
  • Salomat Asrorovna Halimova Department of Biochemistry, Samarkand State Medical University
  • Nasiba Komiljonovna Murtazayeva Department of Biochemistry, Samarkand State Medical University

Keywords:

endothelial dysfunction, atherosclerosis, autoimmune processes, hypercholesterolemia, hyperlipoproteinemia

Abstract

Relevance.

Cardiovascular diseases and, primarily coronary heart disease, remain among the leading causes of disability and mortality worldwide.

Аim. To study the relationship between vascular endothelial dysfunction and hyperlipoproteinemia in experimental atherosclerosis.

Materials and methods. The experiments were carried out on 28 Chinchilla rabbits with an average weight of 2.5-3.0 kg. The action of drugs was studied in dynamics: the initial 3-month condition and after one month of drug administration. The results obtained were compared with those of the control and intact groups.

Results. Long-term administration of cholesterol is accompanied by the development of hypertriglyceridemia, the severity of which depends on the duration of the experiment.

Conclusion. An important role in the development of endothelial dysfunction in hypercholesterolemia is played by a decrease in the synthesis of endothelial nitric oxide and an increase in its active radicals, causing modification of low-density lipoproteins and their deposition in the vascular endothelium

References

Polonskaya A. A., Gorshunova Yu. S., Tolmachev D. A. Cardiovascular diseases as a medical and social problem // Modern Science. - 2021. - S. 110-114.,

Kochurova D.E. Influence of anxiety on the occurrence of coronary heart disease //Forum of Young Scientists. – 2020. – no. 12. - S. 281-288.

Storozhenko P. A. et al. Molecular basis of atherogenesis // Innovation and expertise: scientific works. – 2019. – no. 3 (28). - S. 77. ].

Echeverria C. et al. Endothelial dysfunction in pregnancy metabolic disorders // Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. - 2020. - T . 1866. - no. 2. - S. 165414.

Azim B. et al. The state of free-radical oxidation of lipids in experimental myocardial infarction in rats // European Journal of Molecular & Clinical Medicine. - 2021. - T . 8. - no. 3. - S. 816-820.

Panevina A.S. et al. Endothelium: pro- and antithrombogenic activity of the vessel wall. The current state of the issue // Questions of gynecology. - 2022. - T. 21. - No. 2. - S. 100-106.

Todorov S.S. The role of smooth muscle cells and macrophages in the development of complicated forms of arterial atherosclerosis //Kardiology. - 2019. - T. 59. - No. 1. - S. 57-61 .

Aronov D. M., Bubnova M. G., Drapkina O. M. Pathogenesis of atherosclerosis through the prism of microvascular dysfunction // Cardiovascular therapy and prevention. - 2021. - T. 20. - No. 7. - S. 133-142. .

Stavchikov E. L., Zinovkin I. V. Atherogenic coefficient as a prognostic criterion for glycemic control in patients with type 2 diabetes mellitus complicated by diabetic foot syndrome. – 2021.

Blokhina A. V. et al. Familial dysbetalipoproteinemia: a highly atherogenic and underdiagnosed disease // Cardiovascular therapy and prevention. - 2021. - T. 20. - No. 6. - S. 117-126.

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Published

2023-03-17

How to Cite

Baykulov , A. K., Halimova , S. A., & Murtazayeva , N. K. (2023). VASCULAR ENDOTHELIAL DYSFUNCTIONS WITH HYPERLIPOPROTEINEMIA. GOLDEN BRAIN, 1(7), 4–11. Retrieved from https://researchedu.org/index.php/goldenbrain/article/view/2216